MDC CV 2007-2012 - all variables

MDC CV rescreening 2007-2012: Questionnaire

Contents 

Factors which are likely to have an effect on the emergence of cancer and cardiovascular diseases, such as occupation, physical activity, psychosocial environment, tobacco and alcohol consumption, health, diseases in the family, etc. Other variables are questions about PSA test (only men), hormonal replacement therapy and mammographic screening (only women).

Lines: 3 701
Variables: 125

Source

Data have been derived from the questionnaire filled in by the participating individuals

List of variables

Socially 

Occupation

Physical activity

Smoking

Alcohol consumption

State of health

Diseases in the family

Questions put to men only

Questions put to women only

MDC CV rescreening 2007-2012: Intake of drugs

Contents

Intake of prescribed drugs during a week related to diabetes, gynaecological, lipid disturbance or cardio vascular diseases.

Lines: 3 699
Variables: 50

Source

Data originate from the questionnaire, question 28, filled in by the participating individuals. Nurses at the Clinical Research Unit transferred information of the prescribed drugs from that question to a separate form, from which the data were obtained.

List of variables

MDC CV rescreening 2007-2012: Examination by nurse, incl OGTT

Contents

Data on anthropometry, blood pressure, heart rate, diabetes status and OGTT.

Lines: 3 700
Variables: 15

Source

Data have been derived from the nurse and OGTT form filled in by the nurse at the Clinical Research Unit. Individuals with suspected newly identified diabetes had to give an additional sample or participate in an additional OGTT at the Clinical Research Unit in order to get the diabetes verified.

List of variables

MDC CV rescreening 2007-2012: Sample analyses

Contents

Results from analysis of triglycerides, glucose, cholesterol (incl LDL and HDL), albumin, albumin/krea index and creatinine.

Lines: 3 699
Variables: 12

Source

Blood samples taken of the participant during the examination by the nurse were analysed by Labmedicin Skåne, Malmö.

Data editing

For individuals with multiple results of one type of analysis the result of only the first analysis has been kept.

List of variables

MDC CV rescreening 2007-2012: Ultrasound examination

Contents

Results from the ultrasound examination of the carotid artery.

Lines: 3 734
Variables: 51

Source

Data have been derived from the ultrasound form filled in by the biomedical scientists. All plaques of the patient were measured and evaluated. A maximum of three plaques were entered in the database.
For the ultrasound examination a Siemens Sequioa with a 5-8 MHz transducer was used. A specific study protocol was used. Wall thickening was defined as a thickening of the arterial wall >1,2 mm. When this thickening was focal it was defined as a plaque. Degree of stenosis (Hansen et al, 1996), presence of ulceration and calcification in the plaque and type of plaque was assessed at the ultrasound examination, as were plaque area and diameter reduction. A white area in the plaque was assessed as calcification when a shadow was present below this area.

Data editing

Two separate forms were filled in for individuals examined on both right (dexter) and left (sinister) sides. Data from the two forms were rearranged into one data line with two sets of variables, one for each side.

Reference

Hansen F et al. Accuracy of duplex sonography before carotid endarterectomy - A comparison with angiography. Eur J Vasc Endovasc Surg. 1996 Oct;12(3):331-336.

Östling, G och Nilsson PM. 2012. Sammanställning av variabelinformation som baseras på ultraljudsundersökning av arteria carotis i MKC KVA ÅUS. Opublicerat manuskript. Lund universitet, Inst för Kliniska vetenskaper.

List of variables

MDC CV rescreening 2007-2012: Sample analyses

Contents

Results from analysis of triglycerides, glucose, cholesterol (incl LDL and HDL), albumin, albumin/krea index and creatinine.

Lines: 3 699
Variables: 12

Source

Blood samples taken of the participant during the examination by the nurse were analysed by Labmedicin Skåne, Malmö.

Data editing

For individuals with multiple results of one type of analysis the result of only the first analysis has been kept.

List of variables

MDC CV rescr 2007-2012: Ultrasound examination

Contents

Results from the ultrasound examination of the carotid artery.

Lines: 3 734
Variables: 51  

Source

Data have been derived from the ultrasound form filled in by the biomedical scientists. All plaques of the patient were measured and evaluated. A maximum of three plaques were entered in the database.
For the ultrasound examination a Siemens Sequioa with a 5-8 MHz transducer was used. A specific study protocol was used. Wall thickening was defined as a thickening of the arterial wall >1,2 mm. When this thickening was focal it was defined as a plaque. Degree of stenosis (Hansen et al, 1996), presence of ulceration and calcification in the plaque and type of plaque was assessed at the ultrasound examination, as were plaque area and diameter reduction. A white area in the plaque was assessed as calcification when a shadow was present below this area.

Data editing

Two separate forms were filled in for individuals examined on both right (dexter) and left (sinister) sides. Data from the two forms were rearranged into one data line with two sets of variables, one for each side.

Reference

Hansen F et al. Accuracy of duplex sonography before carotid endarterectomy - A comparison with angiography. Eur J Vasc Endovasc Surg. 1996 Oct;12(3):331-336.

Östling, G och Nilsson PM. 2012. Sammanställning av variabelinformation som baseras på ultraljudsundersökning av arteria carotis i MKC KVA ÅUS. Opublicerat manuskript. Lund universitet, Inst för Kliniska vetenskaper.

List of variables

MDC CV rescreening 2007-2012: IMT

Contents

Results from the IMT measurement of the ultrasound examination of the carotid artery.

Lines: 6 250 (3 712 individuals)
Variables: 10

Source

For the ultrasound examination a Siemens Sequioa with a 5-8 MHz transducer was used. A specific study protocol was used.
IMT and lumendiameter values were measured off line using the Artery Measurement System (AMS) program (Liang et al, 2000). IMT and lumendiameter from the old cohorts (MDC CV base, HOMA and plaque) in this variable list has been re-measured in batch at the same time as the measurement of the current examination. Most individuals have images from the right side, but about 10% do also have images from the left side, especially those examined in the beginning of the study.

Data editing

The off line analysis software generated two separate types of data files with results: bulb (carotid bifurcation) and cca (common carotid artery), respectively. Usually the operator measured on three images per individual and cohort (max 7 images), where each image yielded a separate data line. For the final data set one bulb and one cca data line were selected per individual and cohort based on certain criteria.

Reference

Liang Q et al. A multiscale dynamic programming procedure for boundary detection in ultrasonic artery images. IEEE Trans Med Imaging. 2000 Feb;19(2):127-42. ISSN: 0278-0062. 

Östling, G och Nilsson PM. 2012. Sammanställning av variabelinformation som baseras på ultraljudsundersökning av arteria carotis i MKC KVA ÅUS. Opublicerat manuskript. Lund universitet, Inst för Kliniska vetenskaper.

List of variables

Carotid bifurcation

Common carotid artery

MDC CV rescreening 2007-2012: PWV and PWA

Contents

Results from arterial stiffness measurements. Three data files were created, two with the original mutltiple measurements (PWV_allrec and PWA_allrec), and one with averages (PWV_PWA_mean).

Lines and Variables:

PWV_PWA_mean:    # lines 3 150    # variables 36
PWV_allrec:    # lines 8 973    # variables 13
PWA_allrec:    # lines 9 034    # variables 15

Selection

All participants in the study were invited but out of 3734 individuals only 3150 have results from the PWV/PWA-measurements. The measurements were conducted about 4 to 13 months (median 280 days) after the ultra sound examination, which with few exceptions was the first visit in the study. Some individuals had died or were diseased, other did not accept the invitation. In addition, individuals with unstable heart rhythm (due to e.g. atrial fibrillation or arrhythmia) could not be measured.

Source

For the arterial stiffness measurements a SphygmoCor was used. The output values generated by the machine were means of approximately 10 heart beats. A specific study protocol was used. Blood pressure for the  PWV measurement was taken twice in the right  arm  after a 5 minute rest.  Blood pressure for PWA was measured once before the PWA measurements.
The  pulse wave velocity (PWV) was measured over the aorta. Pulse curves from the carotid and femoral arteries were obtained with a pressure sensitive probe, and the time from the R-wave in an ECG to the beginning of the pulse wave was measured. PWV was automatically calculated as the time difference between carotid pulse–R wave and femoral puls–R wave, divided with the distance between the two measurement points.
Pulse wave augmentation index (PWA) was calculated automatically from the pulse curve obtained from the right radial artery. From this curve also the central blood pressure was automatically calculated.

Data editing

The SphygmoCor machine generated two separate types of data files with results: PWV (Pulse Wave Velocity) and PWA (Pulse Wave Analysis), respectively. Usually the measurements were repeated by the operator 3 times per individual (for PWV up to 5, and for PWA up to 4 times). The repetitions are represented as separate data lines in the files PWV_allrec and PWA_allrec, where the values in each dataline are the mean of approximately 10 heart beats. In the file PWV_PWA_mean averages of the values in the two files mentioned above are given, as a result this file contains only one data line per individual.

Reference

Nilsson, PM och Östling, G. 2012. Sammanställning av variabelinformation som baseras på artärmätningar i MKC KVA ÅUS. Opublicerat manuskript. Lund universitet, Inst för Kliniska vetenskaper.

List of variables

PWV

PWA

PWV_allrec (all records per individual)

PWA_allrec (all records per individual)

MDC CV rescr 2007-2012: Cognitive questionnaire

Contents

The questionnaire contains questions about the participants memory function, capacity for thinking, communication skills, orientability and practical ability, as well as dementia or neurologic disease among relatives.

Lines: 3 330
Variables: 23

Selection

All participants in the study were invited but out of 3734 individuals only 3330 have results from the cognitive questionnaire. The cognitive questionnaire was filled in about 4 to 13 months (median 290 days) after the ultra sound examination, which with few exceptions was the first visit in the study. Some individuals had died or were diseased, other did not accept the invitation.

Source

Data have been derived from the cognitive questionnaire filled in by the participating individuals.

List of variables

MDC CV rescreening 2007-2012: MMT and AQT

Contents

Results from two types of tests for determination of cognitive functions and dementia: Mini Mental Test (MMT) and A Quick Test (AQT)

Lines: 3 329
variables: 18    

Selection

All participants in the study were invited but out of 3734 individuals only 3 329 have results from the MMT/AQT-examinations. The measurements were conducted about 4 to 13 months (median 290 days) after the ultra sound examination, which with few exceptions was the first visit in the study. Some individuals had died or were diseased, other did not accept the invitation.

Source

Data have been derived from the MMT/AQT form filled in by a nurse at the Clinical Research Unit.

List of variables

MDC CV rescreening 2007-2012: MOCA

Contents

Results from cognitive test Montreal Cognitive Assessment (MOCA).

Lines: 861 
variables: 14  

Selection

Testing with MOCA started consecutively on April 29, 2011. All participants in the MMT/AQT examinations were offered the MOCA test from that date with the exception of about 20 individuals due to lack of time by nurse. The MOCA test was performed at the same day as the MMT/AQT examination. Somewhat more than 10 individuals could not perform all tasks in the MOCA test due to visual impairment or color-blindness.

Source

Data have been derived from the MOCA test form filled in by a nurse at the Clinicial Research Unit.

Reference

www.mocatest.org

List of variables