Cancer och dödsorsaker i MKC
MDC Vital Cancer endpoint report 2017
The Malmö Diet and Cancer Study
Department of Clinical Sciences
Skåne University Hospital, Malmö
Lund University
The Malmö Diet and Cancer Study
The EPIC cohort
Vital Status – Cancer Endpoints
End of follow-up: 31 December 2016
Report: 16 November 2017
By Anders Dahlin & Jonas Manjer
Cohort
Lost to follow-up
Vital status
Time of follow-up
Cause-of-death
Cancer endpoints
1. Cohort
Background population: 74 137
Men: 31 513
Women: 42 624
Malmö Diet and Cancer Study (MDC) cohort
Individuals qualify to the MDC cohort if they participated in at least one part of the Malmö Diet and Cancer Study.
Total: 30 446
Men: 12 120
Women: 18 326
EPIC cohort
Individuals qualify to the EPIC cohort if they completed the socio-medical questionnaire, anthropometric measurements and dietary assessment.
Total: 28 098
Men: 11 063
Women: 17 035
Amendments and implementation of new procedures
Year* Description**
2017
- Data from SCB (until Dec 2016) were used as the primary source for death and emigration dates, a few death dates may originate from NAVET (until March 2015), PopregRS (until Nov 2016) or SoS.
2011
- Information of reused (återanvända) Personal Identity Numbers (PIN) was taken into account, diagnoses appearing after the date of death of an MDC participating individual were removed.
- For individuals with changed PINs, data with the new PIN (death, emigration, diagnoses) were included in the endpoint update.
- Date of death as given by SCB has been used (previously dates from SoS were used)
- One individual in the MDC cohort (not in EPIC) was identified with two different PINs, the latest PIN was removed. The new MDC cohort number is 30 446.
* The year when the endpoint update and this endpoint report is finalized, usually last follow-up date is the year before.
** NAVET = National registration data by The Swedish Tax Agency; SCB = Statistics Sweden SoS = The National Board of Health and Welfare; PopregRS = Population register Region Skåne
2. Lost to follow-up
Left the country until 31 Dec. 2016 according to SCB
Population | Number of subjects | Number of subjects in 2015 | Number of subjects in 2016 |
---|---|---|---|
EPIC cohort | 233 | 7 | 9 |
Men | 91 | 1 | 3 |
Women | 142 | 6 | 6 |
3. Vital status
Deaths until 31 Dec. 2016 according to SCB
Population | Number of deaths | Number of deaths in 2015 | Number of deaths in 2016 |
---|---|---|---|
EPIC cohort | 9 827 | 747 | 814 |
Men | 4 945 | 346 | 339 |
Women | 4 882 | 401 | 475 |
4. Time of follow-up
- From date of entry to death, lost to follow-up or to 31 Dec. 2016
Population | Person-Years |
---|---|
EPIC cohort | 556 990 |
Men | 209 685 |
Women | 347 305 |
5. Cause-of-death
- Cause-of-death in the EPIC cohort of 28 098 individuals
Cause-of-death available until 31 Dec. 2016; n=9 787
ICD-9 | ICD-10 | Cause of death | Total | Percent |
---|---|---|---|---|
1-139 | A, B | Certain infectious diseases | 170 | 1,7 |
140-239 | C, D00-D48 | Tumors | 3 613 | 36,9 |
240-279 | E, D80-D89 | Endocrine, metabolic, immunological disease | 261 | 2,7 |
280-289 | D50-D77 | Blood disease | 23 | 0,2 |
290-319 | F | Psychiatric disease | 431 | 4,4 |
320-389 | G, H | Neurological disease | 449 | 4,6 |
390-459 | I | Cardiovascular disease | 3 220 | 32,9 |
460-519 | J | Respiratory disease | 622 | 6,4 |
520-579 | K | Digestive disease | 272 | 2,8 |
580-629 | N | Uro-genital disease | 106 | 1,1 |
630-679 | O | Pregnancy and partus complications | 0 | 0,0 |
680-709 | L | Dermatological disease | 12 | 0,1 |
710-739 | M | Musculoskeletal disease | 41 | 0,4 |
740-759 | Q | Birth defects | 7 | 0,1 |
760-779 | P | Certain perinatal conditions | 0 | 0,0 |
780-799 | R | Symptoms and unspecified disease | 248 | 2,5 |
800-999 | V, W, X, Y | Injuries and poison | 312 | 3,2 |
6. Cancer endpoints
Cancer events
Number of cancer events until 31 Dec 2016 in the EPIC cohort of 28 098 individuals.
Prevalent: date of diagnosis ≤ date of entry
Incident: date of diagnosis > date of entry
Cancer events, total | 14 190 |
Prevalent tumors at baseline | 3 426 |
Men | 525 |
Women | 2 901 |
Incident tumors | 10 764 |
Men | 4 955 |
Women | 5 809 |
Cancer cases total
Number of individuals with cancer in the EPIC cohort of 28 098 individuals.
Prevalent / incident status according to date of first tumour in the studied site.
ICD-7 | Site | Total | ||
---|---|---|---|---|
Prevalent | Incident | Incident 2016 | ||
151 | Stomach | 14 | 158 | 7 |
153 | Colon (excluding rectum) | 97 | 676 | 33 |
154 | Rectum | 73 | 368 | 16 |
153-154 | Colon or rectum | 167 | 1 026 | 49 |
157 | Pancreas | 0 | 197 | 9 |
162 | Trachea, bronchus, lung or pleura | 27 | 757 | 30 |
170 | Breast (invasive) | 473 (3 males) | 1 274 (4 males) | 40 |
170 | Breast (cis+invasive) | 579 (3 males) | 1 344 (5 males) | 40 |
171 | Cervix uteri (invasive) | 86 | 33 | 3 |
171 | Cervix uteri (cis+invasive) | 1 412 | 148 | 4 |
172 | Corpus uteri | 103 | 202 | 3 |
175 | Ovary | 68 | 161 | 3 |
177 | Prostate | 96 | 1 524 | 60 |
180 | Kidney | 37 | 188 | 8 |
181 | Urinary tract, (excluding kidney) | 60 | 548 | 35 |
190 | Malignant melanoma of skin | 173 | 450 | 28 |
191 | Skin (melanoma excl.) | 65 | 828 | 80 |
193 | Nervous system | 52 | 192 | 7 |
200, 201 | Malignant lymphoma | 47 | 279 | 13 |
Cancer cases - men/women
Number of individuals with cancer in the EPIC cohort of 28 098 individuals.
Prevalent / incident status according to date of first tumor in the studied site.
ICD-7 | Site | Prevalent | Incident | ||
---|---|---|---|---|---|
Male | Female | Male | Female | ||
151 | Stomach | 9 | 5 | 98 | 60 |
153 | Colon (excluding rectum) | 50 | 47 | 309 | 367 |
154 | Rectum | 28 | 45 | 192 | 176 |
153-154 | Colon or rectum | 76 | 91 | 490 | 536 |
157 | Pancreas | 0 | 0 | 76 | 121 |
162 | Trachea, bronchus, lung or pleura | 14 | 13 | 370 | 387 |
170 | Breast (invasive) | 3 | 476 | 4 | 1 270 |
170 | Breast (cis+invasive) | 3 | 576 | 5 | 1 339 |
171 | Cervix uteri (invasive) | - | 86 | - | 33 |
171 | Cervix uteri (cis+invasive) | - | 1 412 | - | 148 |
172 | Corpus uteri | - | 103 | - | 202 |
175 | Ovary | - | 68 | - | 161 |
177 | Prostate | 96 | - | 1 524 | - |
180 | Kidney | 17 | 20 | 99 | 89 |
181 | Urinary tract, (excluding kidney) | 43 | 17 | 388 | 160 |
190 | Malignant melanoma of skin | 66 | 107 | 216 | 234 |
191 | Skin (melanoma excl.) | 38 | 27 | 416 | 412 |
193 | Nervous system | 17 | 35 | 72 | 120 |
200, 201 | Malignant lymphoma | 21 | 26 | 128 | 151 |