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Cancer och dödsorsaker i MKC

MDC Vital Cancer endpoint report 2017

The Malmö Diet and Cancer Study
Department of Clinical Sciences
Skåne University Hospital, Malmö
Lund University

The Malmö Diet and Cancer Study
The EPIC cohort

Vital Status – Cancer Endpoints

End of follow-up: 31 December 2016
Report: 16 November 2017
 

By Anders Dahlin & Jonas Manjer

  1. Cohort
  2. Lost to follow-up
  3. Vital status
  4. Time of follow-up
  5. Cause-of-death
  6. Cancer endpoints

1. Cohort

Background population: 74 137
Men: 31 513
Women: 42 624

Malmö Diet and Cancer Study (MDC) cohort
Individuals qualify to the MDC cohort if they participated in at least one part of the Malmö Diet and Cancer Study.

Total: 30 446
Men: 12 120
Women: 18 326

EPIC cohort
Individuals qualify to the EPIC cohort if they completed the socio-medical questionnaire, anthropometric measurements and dietary assessment.

Total: 28 098
Men: 11 063
Women: 17 035

Amendments and implementation of new procedures
Year* Description**
2017
- Data from SCB (until Dec 2016) were used as the primary source for death and emigration dates, a few death dates may originate from NAVET (until March 2015), PopregRS (until Nov 2016) or SoS.
2011
- Information of reused (återanvända) Personal Identity Numbers (PIN) was taken into account, diagnoses appearing after the date of death of an MDC participating individual were removed.
- For individuals with changed PINs, data with the new PIN (death, emigration, diagnoses) were included in the endpoint update.
- Date of death as given by SCB has been used (previously dates from SoS were used)
- One individual in the MDC cohort (not in EPIC) was identified with two different PINs, the latest PIN was removed. The new MDC cohort number is 30 446.

* The year when the endpoint update and this endpoint report is finalized, usually last follow-up date is the year before.
** NAVET = National registration data by The Swedish Tax Agency; SCB = Statistics Sweden SoS = The National Board of Health and Welfare; PopregRS = Population register Region Skåne

2. Lost to follow-up

Left the country until 31 Dec. 2016 according to SCB

PopulationNumber of subjectsNumber of subjects in 2015Number of subjects in 2016
EPIC cohort      23379
Men9113
Women14266

 

3. Vital status

Deaths until 31 Dec. 2016 according to SCB

PopulationNumber of deathsNumber of deaths in 2015Number of deaths in 2016
EPIC cohort       9 827747814
Men4 945346339
Women4 882401475

4. Time of follow-up

  1. From date of entry to death, lost to follow-up or to 31 Dec. 2016
PopulationPerson-Years
EPIC cohort556 990
Men209 685
Women347 305

5. Cause-of-death

  1. Cause-of-death in the EPIC cohort of 28 098 individuals
    Cause-of-death available until 31 Dec. 2016; n=9 787
ICD-9ICD-10Cause of deathTotalPercent
1-139A, BCertain infectious diseases1701,7
140-239   C, D00-D48Tumors3 61336,9
240-279E, D80-D89Endocrine, metabolic, immunological disease 2612,7
280-289D50-D77Blood disease230,2
290-319FPsychiatric disease4314,4
320-389G, HNeurological disease4494,6
390-459ICardiovascular disease3 22032,9
460-519JRespiratory disease6226,4
520-579KDigestive disease2722,8
580-629NUro-genital disease1061,1
630-679OPregnancy and partus complications00,0
680-709LDermatological disease120,1
710-739MMusculoskeletal disease410,4
740-759QBirth defects70,1
760-779PCertain perinatal conditions00,0
780-799RSymptoms and unspecified disease2482,5
800-999V, W, X, YInjuries and poison3123,2

6. Cancer endpoints

Cancer events
Number of cancer events until 31 Dec 2016 in the EPIC cohort of 28 098 individuals.
Prevalent: date of diagnosis ≤ date of entry
Incident: date of diagnosis > date of entry

Cancer events, total14 190
Prevalent tumors at baseline3 426
          Men525
          Women2 901
Incident tumors10 764
          Men4 955
          Women5 809

Cancer cases total

Number of individuals with cancer in the EPIC cohort of 28 098 individuals.
Prevalent / incident status according to date of first tumour in the studied site.

ICD-7SiteTotal  
  PrevalentIncidentIncident 2016
151Stomach141587
153Colon (excluding rectum)9767633
154Rectum7336816
153-154    Colon or rectum1671 02649
157Pancreas01979
162Trachea, bronchus, lung or pleura2775730
170Breast (invasive)473 (3 males)1 274 (4 males)40
170Breast (cis+invasive)579 (3 males)1 344 (5 males)40
171Cervix uteri (invasive)86333
171Cervix uteri (cis+invasive)1 4121484
172Corpus uteri1032023
175Ovary681613
177Prostate961 52460
180Kidney371888
181Urinary tract, (excluding kidney)6054835
190Malignant melanoma of skin17345028
191Skin (melanoma excl.)6582880
193Nervous system521927
200, 201Malignant lymphoma4727913

Cancer cases - men/women

Number of individuals with cancer in the EPIC cohort of 28 098 individuals.
Prevalent / incident status according to date of first tumor in the studied site.

ICD-7SitePrevalent Incident 
  MaleFemaleMaleFemale
151Stomach959860
153Colon (excluding rectum)5047309367
154Rectum2845192176
153-154     Colon or rectum7691490536
157Pancreas0076121
162Trachea, bronchus, lung or pleura1413370387
170Breast (invasive)347641 270
170Breast (cis+invasive)357651 339
171Cervix uteri (invasive)-86-33
171Cervix uteri (cis+invasive)-1 412-148
172Corpus uteri-103-202
175Ovary-68-161
177Prostate96-1 524-
180Kidney17209989
181Urinary tract, (excluding kidney)4317388160
190Malignant melanoma of skin66107216234
191Skin (melanoma excl.)3827416412
193Nervous system173572120
200, 201Malignant lymphoma2126128151