Malmö Preventive Project - MPP
In the 1970s, a primary preventive project started at the Clinic of Internal Medicine, University Hospital, Malmö, under the guidance of Professor Bertil Hood.
Malmö Preventive Project (or Malmö Preventive Medicine) began inviting all men from certain birth cohorts in 1974 (born 1921-1949) and in 1974 they began to examine women (born 1926-1949) . When the project was completed in 1991, approximately 22,000 men and 11,000 women had participated. This represented about 70 percent of all invited. Recruitment and data collection have previously been described in several references.
The baseline survey contained a questionnaire that mainly addressed lifestyle and socio-economic factors. All participants submitted a blood test and underwent a physical examination to measure blood pressure, height and weight, and evaluate lung function by spirometry. Several laboratory parameters were analyzed directly, plasma and serum samples were saved at minus 20° C. In 18,000 subjects an oral glucose tolerance test (OGTT) was carried out.
After five to ten years, the surveys were repeated for approximately 6,100 individuals (mainly men), the so-called 6-year re-exam screening.
In the early 2000´s, everyone who participated in the baseline survey was invited to a re-examination. It included a shortened questionnaire and blood sampling. This time both serum, plasma and DNA were saved. A total of over 11,500 men and 6,500 women participated in the re-examination.
- Berglund G, Nilsson P, Eriksson KF, Nilsson JA, Hedblad B, Kristenson H, Lindgärde F. Long-term outcome of the Malmö preventive project: mortality and cardiovascular morbidity. J Intern Med. 2000 Jan;247(1):19-29.